× Development of automated synthesis procedures for radiopharmaceuticals with high molar activity (A_m) and quality according to GMP regulations

• Small molecules
• Peptides
• Affibodies (Fab)

× Optimising ¹⁸F-radiofluorination methods (electrophilic, transition metal mediated and nucleophilic) for simplicity and high  A_m (Fig. 1)

× Optimising target performance, ¹¹C-labelling agent pathways and synthesis methods for simplicity, high yields and A_m (Fig. 2)

× Radiometal labelling of novel chelating agents, their in vivo characterisation and utilisation in the labelling of bioactive macromolecules for PET imaging